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Roche indicated that patients seeking maximum weight loss might choose more potent therapies like its experimental dual-acting enicepatide, while others might prefer more modest weight loss with fewer side effects for easier long-term adherence

The specific tri-agonist designation allows this single compound to engage three independent physiological pathways at the same time

Systematic reviews and meta-analyses of randomised controlled trials suggest that berberine may modestly reduce fasting blood glucose, HbA1c (a marker of long-term glucose control), and post-meal glucose levels in people with type 2 diabetes or non-diabetic hyperglycaemia (prediabetes)
