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Herein, the oxidation state of the pterin ring is perhaps the deciding factor assigning its bifunctional role because the reduced form of pterin such as dihydro or tetrahydro form of pterin moiety may perhaps participate in folate synthesis whereas the fully oxidized form may perhaps not undergo folate synthesis and exist as a pterin pool creating various energy levels to donate and accept the charge (Fig

Besides, in rats with inflamed intestines, PER downregulated the toll-like receptor 4 (TLR4), NF-B, and c-Fos/c-Jun pathways at the molecular level (Sayed et al

Eftekhari A, Azarmi Y

Nature 468 (7321), 310315

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Chemosphere 243:125308 Sharif R, Xie C, Zhang H, Arnao M, Ali M, Ali Q, Muhammad I, Shalmani A, Nawaz M, Chen P, Li Y (2018) Melatonin and its effects on plant systems