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Consequently, targeted therapies aimed at hypoxic signaling pathways necessitate precise control of drug dosages and timing to mitigate side effects and the development of resistance

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Considering that this study focused mainly on patients above the 300-line, this would be a reasonable level at which to start increasing NAC dosing

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This interaction inhibits Keap1-mediated ubiquitination and degradation of NRF2, resulting in the upregulation of antioxidant genes and contributing to chemotherapy resistance in NSCLC [100]