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The ITPR1 gene is located on chromosome 3p26.1 and is composed of 63 exons that generate three alternatively spliced mRNAs encoding three distinct isoforms of the receptor

Acidosis resulting mainly from dietwhich can trigger it directly or indirectlycan trigger bacterial transformations, which in turn can boost acidosis mostly via their products and infections (positive feedback loop)

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The primary method of prevention revolves around avoiding behaviours and practices that can lead to exposure to the blood of an infected individual