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Electrophysiology in mice Extracellular recordings of LH in freely moving Vgat-IRES-cre mice Multi-unit recordings were performed using a Multichannel Acquisition Processor system (Plexon, Dallas, Texas) and a Med Associates (Fairfax, VT) interphase to record behavioral events simultaneously

When dosed 46 hours apart, the compounds avoid competitive binding while maximising fat oxidation, energy expenditure, and mitochondrial efficiencydelivering outcomes neither achieves at full capacity alone

When tirzepatide activates the GLP-1 receptor, several beneficial effects occur: Increased Insulin Secretion : In response to high blood glucose levels, the pancreas secretes more insulin