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85(3): p

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(2016) 113:E547280

Though de novo Cer production takes place in the ER [210], it has been suggested that long-chain bases are acylated in hepatic mitochondria

The commercial question is whether both ingredients can be delivered in a stable, compliant, and consumer-friendly dosage form without caking, off-taste, capsule-fill limitations, or overstated weight-management claims

The latter is defined by ten type-A amphipathic alpha-helical repeats that are organized into alternating 11-residue and 22-residue segments (Figure 3) [12, 13]
