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The University of Maryland Medical Center research indicates that bypassing digestive absorption increases bioavailability by 85% compared to oral supplementation

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Fulvestrant is the first SERD approved for clinical use to treat advanced and metastatic breast cancer
Raises NAD+ and SAM The same study showed that NAD+ and S-adenosyl-methionine (SAM) both went up after NNMT inhibition

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WIPI2b, a WIPI2 isoform, directly interacts with ATG16L1 and recruits the complex to the phagophore, where ATG16L1 acts similar to E3 enzymes to promote the lipidation of ATG8 family proteins (65)
