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It was additionally identified as a host cell factor of HCV 46 and demonstrated to be a relevant host factor for SARS-CoV-2 infections in two CRISPR-Cas9 knockout screens 33,34

Endogenously generated reactive oxygen species (ROS) and reactive nitrogen species (RNS) involve enzymes like peroxidase (POD), xanthine oxidase (XO), lipoxygenase (LOX), glucose oxidase, myeloperoxidase (MPO), nitric oxide synthase (NOS), cyclooxygenases (COX), and the NOX complex (Martins et al., 2021)

Koshland, D

Orthostatic challenge causes distinctive symptomatic, hemodynamic and cognitive responses in Long COVID and myalgic encephalomyelitis/chronic fatigue syndrome

10.1016/j.ymben.2018.05.015

doi: 10.1097/MIB.0000000000000344 225 HornigMMontoyaJGKlimasNGLevineSFelsensteinDBatemanLet al
