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In contrast, positional polar amine substitutions around the quinolinium core not only improved NNMT inhibition as noted previously,[17] but also enabled favorable passive and active transport across membranes (Tables 1 and 2)

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This, in turn, results in a range of lower urinary tract symptoms (LUTS), encompassing urinary irritation (urgency, frequency, nocturia, reduced urine volume, and urge incontinence), obstruction (thin urine stream, interrupted urination, weak flow, tense urination, or prolonged urination), and post-micturition symptoms (incomplete emptying or post-void dribbling