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Notably, the germline tumor phenotype of puf-8(q725) mutants is dramatically enhanced by the additional loss of LIP-1 (an MPK-1/ERK inhibitor) [87]
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A less careful brand might just pick a number that a few cells can achieve

In vivo, mice on a high-fat diet (HFD) supplemented with TMAO exhibited greater colonic mucosal damage, reduced tight junction proteins, and elevated inflammatory markers compared to those on HFD alone, supporting the notion that TMAO induces tissue injury
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