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In: Preedy VR (ed) Apoptosis: Modern Insights into Disease from Molecules to Man

Immunosuppressive Activity Gliotoxin has been reported to induce immunosuppressive activity via cell apoptosis mediated by the repression of phagocytosis and macrophages [33] as well as the suppression of the proliferation of giant cells and T-cells [33]

[DOI] [PMC free article] [PubMed] [Google Scholar] 228.Chuaiphichai S., Chu S.M., Carnicer R., Kelly M., Bendall J.K., Simon J.N., Douglas G., Crabtree M.J., Casadei B., Channon K.M

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Dysbiosis may also promote excessive activation of T helper 17 (Th17) cells while impairing Treg function, thereby disrupting the balance between pro-inflammatory and anti-inflammatory immune responses (46, 47)