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The GRX1-roGFP2 constructs show localization in the nucleus because the fusion protein can diffuse through the nuclear pores (Meyer et al., 2007)

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The applicant further stated that the Breakthrough Device designation applies to two clinical scenarios: a de novo system where a patient receives the Aveir TM Dual-Chamber Leadless Pacemaker, or an upgrade system where a patient already has a ventricular leadless pacemaker and is upgraded to the Aveir TM Dual-Chamber Leadless Pacemaker by receiving the Aveir TM AR Leadless Pacemaker

Glutamate, as the primary excitatory neurotransmitter, activates a range of receptors, leading to depolarization of postsynaptic neurons and increased neuronal firing