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GSCs, as a highly specialized population of stem cells, play a crucial role in the progression and recurrence of GBM due to their ability to self-renew and continuously generate new tumor cells [152]

10.3390/biom8040170 67 NathB.LevinI.CsakT.PetrasekJ.MuellerC.KodysK.et al (2011)

However, clinical evidence does not support simultaneous use of both medications, and combining them introduces safety concerns without proven benefit
Ageeva, T., Rizvanov, A., & Mukhamedshina, Y

Similar experiments were also performed in the presence of BACH1 BTB to demonstrate that both native and neosubstrates can bind simultaneously
