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Standardizing these protocols is crucial for maximizing the benefits of melatonin while minimizing potential side effects

Specific barriers that participants face may include (1) mistrust, (2) lack of comfort with the clinical trial process, (3) lack of information about clinical trials, (4) time and resource constraints associated with participation, and (5) lack of awareness about the existence and importance of clinical trials (Clark et al., 2019)

But individual responses vary, and monitoring is appropriate

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Additionally, some payers limit the frequency of injections