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Discovery of 2-vinyl-10H-phenothiazine derivatives as a class of ferroptosis inhibitors with minimal human Ether-a-go-go related gene (hERG) activity for the treatment of DOX-induced cardiomyopathy

To pinpoint the steps of mitochondrial metabolism sensitive to SAM depletion, we first determined which enzyme was responsible for cataplerotically removing KG from the TCA cycle (Fig

[DOI] [PMC free article] [PubMed] [Google Scholar] 159.Takatani-Nakase T

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