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bacterial and host-derived glutathione are required to activate prfa Discovery of a utilization pathway in Francisella that shows functional divergence between environmental pathogenic species: Cell Host & Microbe Diverse roles of low-molecular weight

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bacterial and host-derived glutathione are required to activate prfa Discovery of a utilization pathway in Francisella that shows functional divergence between environmental pathogenic species: Cell Host & Microbe Diverse roles of low-molecular weight

PeralesPuchalt J, Peltzer J, FracachanCabrera M, et al

bacterial and host-derived glutathione are required to activate prfa Discovery of a utilization pathway in Francisella that shows functional divergence between environmental pathogenic species: Cell Host & Microbe Diverse roles of low-molecular weight

The method involved vector construction, agroinfiltration of protein expression constructs in plants, biotin treatment, protein extraction and desalting, quantification, and affinity purification of biotinylated proteins

bacterial and host-derived glutathione are required to activate prfa Discovery of a utilization pathway in Francisella that shows functional divergence between environmental pathogenic species: Cell Host & Microbe Diverse roles of low-molecular weight

binds IGF-binding proteins poorly, so it is ~10x more potent than IGF-1 in vitro with a very short half-life

bacterial and host-derived glutathione are required to activate prfa Discovery of a utilization pathway in Francisella that shows functional divergence between environmental pathogenic species: Cell Host & Microbe Diverse roles of low-molecular weight

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bacterial and host-derived glutathione are required to activate prfa Discovery of a utilization pathway in Francisella that shows functional divergence between environmental pathogenic species: Cell Host & Microbe Diverse roles of low-molecular weight

Furthermore, upregulation of CD36, a fatty acid transporter protein, has been observed in MZB and B1 cells, which can promote fatty acid absorption and ferroptosis sensitivity (108)

bacterial and host-derived glutathione are required to activate prfa Discovery of a utilization pathway in Francisella that shows functional divergence between environmental pathogenic species: Cell Host & Microbe Diverse roles of low-molecular weight

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