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The possible reason is that NNMT is not a major methyltransferase in the liver

Hormonal shifts: Declines in growth hormone, estrogen, or testosterone affecting metabolism

Allergic reactions to proprietary preparations of vitamin B12 might be due to substances added to the solutions as preservatives or for other reasons, to impurities from the production, or to the vitamin B12 itself

The arc from an encouraging 12-week readout to a null 24-week pivotal result is a textbook example of that shrinkage, and it is a pattern seen across the metabolic-drug field, not a quirk of this peptide

& Olufunwa, R