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In summary, the molecular systems integration of oxidative stress and C1 metabolism provides two critical insights: 1) formaldehyde detoxification in C1 metabolism is perturbed by oxidative stress resulting in significant up gregulation of formaldehyde (Figure 9(a), Figure 10(a), Figure 11(a), Figure 12(a) and Figure 13(a)), and 2) gluthatione production is perturbed resulting in its significant downregulation and depletion (Figure 9(b), Figure 10(b), Figure 11(b), Figure 12(b) and Figure 13(b))

Indeed, the formation of TM4SF5-enriched MLCSs upon glucose repletion reduced mitochondrial length

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Arch Biochem Biophys 704:108869