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doi: 10.1038/nature10812 29 CoxC

Recent advances in the genetics of autoimmune disease

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BefA, a microbiota-secreted membrane disrupter, disseminates to the pancreas and increases cell mass

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To fully harness the therapeutic potential of GLP-1R activation, an experimental structural basis (PDB entry 4ZGM) of the GLP-1-GLP-1R interaction is essential for the design of semaglutide analogues, where site-specific missense mutations are engineered into its peptide backbone to establish additional stabilizing interactions with the extracellular domain (ECD) of GLP-1R