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In HFD-induced NAFLD rats, the hepatoprotective effect of Jiaogulan (Gynostemma pentaphyllum (Thunb.) Makino) has been correlated with specific modulations of the gut microbiota (e.g., a reduced Firmicutes/Bacteroidetes ratio, increased Lactococcus, decreased Ruminococcus) and the preservation of intestinal barrier integrity, pointing to microbiota-mediated pathways as a likely component of its action [133]

The MTHFR gene provides instructions for making the MTHFR enzyme (methylenetetrahydrofolate reductase) that helps convert folate (vitamin B9) into its active form: L-methylfolate.* This active folate is the key ingredient in producing methyl groupstiny chemical tags that your body uses in dozens of reactions, including: DNA repair, neurotransmitter synthesis, hormone metabolism, cardiovascular support, and detoxification.* The whole process is called methylation, and without enough methyl groups, your bodys cellular cleanup crews start falling behind on their tasks.* Detox Pathways That Depend on Methylation Methylation affects detox in two major ways: Breaking Down Hormones Estrogen, for example, requires methylation for efficient breakdown and elimination

The dependence of the final equilibrium concentration on body mass is not shown

Feelders RA, de Bruin C, Pereira AM, Romijn JA, Netea-Maier RT, Hermus AR, Zelissen PM, van Heerebeek R, de Jong FH, van der Lely AJ, de Herder WW, Hofland LJ, Lamberts SW

Disagreements were resolved through cross-validation by a fourth and fifth reviewer

Understanding how these pathways intersect and influence each other will inform the rational design of combination therapies that exploit their complementary mechanisms