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10.1016/j.jri.2024.104249 36 ShiL.LiuY.LiM.LuoZ

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(2) Cross-nutrient common mechanistic gaps and future research directions Across all nutrient categories, three critical gaps in mechanistic understanding persist and must be addressed in future research: Quantification of microbiota-metabolite-depression thresholds: for example, the minimum amount of dietary fiber required to elevate fecal butyrate concentrations to levels that alleviate depressive symptoms remains unclear

In particular, glutamine metabolism has attracted much attention as a therapeutic target because cancer cells are heavily reliant on this amino acid for growth and proliferation 3

Zhuo M, Small SA, Kandel ER, Hawkins RD