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However, systemic effects from distant-site injection are also documented, and for diffuse neuropathies affecting multiple nerve territories, systemic administration may provide more uniform coverage

This drawback can be due to only one side of the NO-system employed in the studies (i.e., decreased function by L-NAME application) while the other part remained unchecked (i.e., over-increased function by L-arginine, and vice versa) [124,125]

Alpha-cell paracrine signaling in the regulation of beta-cell insulin secretion

Many pathological conditions are resultant of dysfunctional control systems, exemplified by tumors, which are abnormal and unregulated cellular proliferations typically driven by genetic aberrations

Another example involves a plant using a makeup water source high in conductivity, alkalinity, sulfates, and chloride, while operating at relatively high cycles of concentration for a galvanized cooling tower

doi: 10.1016/j.ccell.2020.06.001