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[DOI] [PMC free article] [PubMed] [Google Scholar] 159.Lehmann M, Korfei M, Mutze K, Klee S, Skronska-Wasek W, Alsafadi HN, Ota C, Costa R, Schiller HB, Lindner M, et al

Beyond that window, potency loss accelerates: studies on similar melanocortin peptides show 1525% degradation by day 45 and upward of 40% loss by day 60, even under continuous refrigeration

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IDO mediated tryptophan catabolism reduces tryptophan availability, which inhibits Teff proliferation and can indirectly activate or de novo induce pTregs [108, 109]