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4 Regulatory mechanisms of L-carnitine on hepatocyte function Clinical evidence indicates that L-carnitine improves liver function in NAFLD patients, reflected by reduced serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels (37, 63)

Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality

Supplementation with olive oil (four tablespoons per day) or mixed nuts (approximately one ounce of walnuts, hazelnuts, and almonds per day) for about five years resulted in a significant, 30 percent reduction in the risk of major cardiovascular events (heart attack, stroke, and cardiovascular death)

(iii) Most importantly, TMAO may be just one of many factors that influence atherosclerosis and its complications

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Therefore, lipid-overloaded macrophages turn into foam cells, which is one of the earliest cellular hallmarks of the atherosclerotic process (Bobryshev, 2006