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10.1038/nbt.4140

The amide moiety adjacent to the covalent bond to U46 is present in two alternative conformations where the oxygen atom forms a hydrogen bond to the side chains of Trp136 and of Asn137, respectively

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VPAC2 in the GI tract VPAC2 receptors are predominantly expressed in smooth muscles throughout the GI tract and in vascular smooth muscles in humans 49 and mice 50

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