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DAMPs, endogenous molecules including DNA, RNA, and proteins, are produced in response to cellular injury, death or stress

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Ethics declarations Competing interests Yvonne Janssen-Heininger and Vikas Anathy hold patents: United States Patent No

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The diagnosis is established by: Low activity of -glutamyl transpeptidase in nucleated cells such as leukocytes or cultured skin fibroblasts

No obstante, las acciones del IGF-1 se atenan en el contexto de la enfermedad renal, que puede deberse a la presencia de factores inhibidores, como las protenas de unin al IGF, y a la incapacidad de activar la sealizacin intracelular a pesar de una expresin normal del receptor de IGF-1 en la superficie celular