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Biologics work by selectively blocking specific cytokines, such as IL-23 and IL-17, that signal to the skin to cause inflammation and rapid cell turnover, says Marisa Garshick, MD, a dermatologist in New York and New Jersey, and a clinical assistant professor of dermatology at NewYork-Presbyterian Weill Cornell Medicine

Hao Y, Samuels Y, Li Q, Krokowski D, Guan BJ, Wang C, Jin Z, Dong B, Cao B, Feng X, Xiang M, Xu C, Fink S, Meropol NJ, Xu Y, Conlon RA, Markowitz S, Kinzler KW, Velculescu VE, Brunengraber H, Willis JE, LaFramboise T, Hatzoglou M, Zhang GF, Vogelstein B, Wang Z

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TB-500: What the Research Shows TB-500 is a synthetic peptide centered on the LKKTETQ actin-binding motif of Thymosin Beta-4 (T4), the major actin-sequestering protein in mammalian cells

[71] However, more evidence is needed to prove this unequivocally