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Until recently they have had little support from the two dominant GLP-1 drug makers, Novo Nordisk and Eli Lilly who have not considered addition a high prioroty (Sheridan)

A meta-analysis of 13 randomized placebo-controlled trials with 1183 participants with T1D reported small reductions in BMI, insulin requirements, total and LDL-C, but no differences in A1C, HDL-C, or triglyceride levels

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However, once reconstituted with bacteriostatic water , the reconstituted solution follows the same storage rules as pre-made liquid formulations

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If injection site reactions bother you, semaglutide has the cleaner profile