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GlyT1 is primarily localized in astrocytes surrounding glycinergic and glutamatergic synapses and is widely distributed throughout the CNS

GSH/GSSG assay was performed by diluting the acid supernatant (5-fold) with ice-cold dilution buffer (250 mM HEPES, pH 7.5)

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For instance, by potentially increasing serotonin levels, Semax may improve mood and decrease anxiety, while optimizing dopamine might enhance motivation and reward processing

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In the case of the essential amino acid sensor, GCN2, we predicted it would play a key role in detecting the immediate decrease in methionine and mediating the subsequent responses, but its absence failed to prevent either the acute transcriptional increase in hepatic Fgf21 and other ATF4 target genes (supplementary Fig