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The thresholds for positive Type 2 biomarkers were defined as follows: BEC 300 cells/L, serum total IgE 75 kU/L with features of atopy, and FeNO 25 ppb, in accordance with previous definitions [9, 10, 13]

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10.1111/j.1530-0277.2008.00754.x 47 FlorezG.Garcia-PortillaP.AlvarezS.SaizP

Nrf2-dependent immunomodulation by sulforaphane improves bacterial phagocytosis in COPD macrophages and inhibits bacterial burden and inflammation in cigarette smoke-exposed mice

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For heart patients, it is important to consider the heart pumping (LVEF), and usually it should be given to patients with poor heart function under 30% LVEF, except few cases when it is really important