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It is used to support fat metabolism and steady energy as part of a broader weight management plan, not as a standalone weight loss treatment

Cell culture studies In laboratory studies using 3T3-L1 adipocytes, a commonly used fat cell line, researchers found that 5-amino-1mq significantly reduced intracellular levels of 1-methylnicotinamide, confirming that it was successfully inhibiting NNMT

The responsible approach in 2025 dictates that any advanced health optimization strategy, particularly one involving novel combinations, must be guided by scientific evidence and robust medical oversight

PMC 1769668

So it may be that the liver has to work extra hard to detoxify the body when its low 0on B12, even when there's no liver damage
