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Interestingly, there is a gender difference in response to GH treatment with men being more responsive in terms of IGF-I generation and fat loss during therapy, most probably due to men having lower estrogen levels that negatively impact the effect of GH on IGF-I generation in the liver (38)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 23.Rushworth G.F., Megson I.L

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