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In addition, many phase 1 clinical trials are testing the efficacy of CAR therapy in solid malignancies by targeting key oncogenic drivers, such as human epidermal growth factor receptor 2 (HER2) and epithelial growth factor receptor (EGFR), which are amplified in many cancers (176)

This method allows for higher concentrations to be administered, potentially enhancing its therapeutic effects

[PubMed: 8097916] 421

These tumours may involve the optic nerve, chiasm and/or hypothalamus

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ZO1 was detected using ZO1 rabbit polyclonal antibodies (#61-7300, ThermoFisher, Waltham, USA) at a concentration of 5 g/mL overnight