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doi:10.1007/s10620-021-07110-2

Interleukin-6 signalling regulates vascular endothelial growth factor-C synthesis and lymphangiogenesis in human oral squamous cell carcinoma

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Thus, in addition to being apparently GH-independent, the testicular functions of IGF-I seem to be served by its local production (autocrine/paracrine action) without a major endocrine contribution by the circulating form of this factor
