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The aim is to separate promising ideas from treatments that have been properly tested in humans, especially when Crohns disease or ulcerative colitis may be active

Despite most prokaryotes and animals possess enzymes that require B12 as cofactor, only some bacteria and archaea are able to synthesize B12 de novo 3

Methionine plays a role in breaking down fats and aiding in the bodys natural ability to enter or maintain ketosis

When it complicates another condition (e.g., cancer cachexia), it is assigned as secondary with the underlying disease first

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By helping to convert homocysteine into other beneficial substances, B12 contributes significantly to cardiovascular health
