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This rapid proliferation has two requirements that depend critically on B12: 1

AOD 9604 and Cartilage / Joint Research Interest in AOD 9604 later shifted toward cartilage repair and osteoarthritis models : In a collagenase-induced knee osteoarthritis (OA) rabbit model , weekly intra-articular injections of AOD 9604 (0.25 mg), with or without hyaluronic acid (HA), enhanced cartilage regeneration compared with saline controls

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The serial changes in the wedge angles were as follows: pre-op: 17.2, immediately post-op: 12.4, post-op 1 month (1 m): 13.5, post-op 6 months (6 m): 14.1, post-op 12 months (12 m): 14.3, post-op 24 months (12 m): 17, and post-op 36 months (36 m): 15
