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Notably, elevated TMAO concentrations induce oxidative stress and activate the NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome in human fetal colon cells, suggesting that TMAO triggers inflammasome activation and promotes an inflammatory response in the intestinal endothelium (17)

If you carry reduced-function variants, your baseline enzyme activity is already lower before any dietary or lifestyle factors enter the picture

Monotherapy with tadalafil or tamsulosin similarly improved lower urinary tract symptoms suggestive of benign prostatic hyperplasia in an international, randomised, parallel, placebo-controlled clinical trial

doi: 10.1007/s12265-021-10115-x 113 VerhaarBJHProdanANieuwdorpMMullerM

Store in a cool dry place, out of the reach of young children