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In the course of the experiments, tert-butyl hydroperoxide (TBHP) was used to induce oxidative stress in annulus fibrosus cells (AFCs) and nucleus pulposus cells (NPCs)

Moreover, the depletion of GSH triggers an apoptotic cascade in lymphocytes leading to lymphopenia, which is directly related to severe disease and high mortality, particularly in COVID-19 patients [6870]

School-aged children (5-6 years) typically exhibit muscle weakness, elevated transaminases, and heart failure (hypertrophic or dilated cardiomyopathy).1,2 Onset is extremely rare in adolescence or adulthood

Also, it is important to note that synthetic retinoids, as well as high-dose vitamin A, may cause birth defects and should not be used orally or topically during pregnancy

In addition, a prognostic model of human GBMs and ROS showed that high expression of ROS-related genes such as HSPB1, LSP1 and PTX3 was closely associated with M2 macrophages and correlated with shorter survival of GBM patients

J Pharmacol Exp Ther 256:11891194 Shigesawa T, Sato C, Marumo F (1992) Significance of plasma glutathione determination in patients with alcoholic and non-alcoholic liver disease