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[PUBMED Abstract] Nishikawa T, Inagaki J, Nagatoshi Y, et al.: The second therapeutic trial for children with hematological malignancies who relapsed after their first allogeneic SCT: long-term outcomes

Translation to humans remains uncertain due to physiological differences

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Enhanced tumour cortisol production was shown to promote an anti-inflammatory environment by attraction and activation of regulatory T cells (Treg), which are known to suppress conventional T-cell activity [184]

Treatment with silibinin elevated the phosphorylation of Akt, increased the expression of Wnt5a and Lef1, and promoted the TCF/Lef reporter activity

[00:18:52] Nick: For sure
