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[8] NADPH is needed for reductive biosynthesis , such as the synthesis of fatty acids, cholesterol, steroid hormones and two non-essential amino acids, proline and tyrosine, from glutamate and phenylalanine, respectively, as well as for the reduction of oxidized glutathione

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These men were examined medically in 1960

Acetyl-CoA enters the cycle after either oxidative breakdown of fatty acyl-CoAs within the mitochondria or after conversion from pyruvategenerated from glycolysis in the cytosolby the mitochondrial pyruvate dehydrogenase complex

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Mutation of putative phosphorylation sites or truncation of the C terminal tail of OR have been extensively used to delineate the role of phosphorylation in desensitization