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effects are dose-dependent and not observed at low doses/short terms

Studies have suggested the association of c-MET expression with expression of immunoregulatory molecules such as programmed cell death ligand (PDL-1) and indoleamine-2,3-dioxygenase (IDO) in cancer cells [69]

Several risk factors predispose individuals to vitamin B12 deficiency beyond medication effects

doi: 10.1038/cdd.2013.22 137 FahnestockMMichalskiBXuBCoughlinMD