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Many of the pathophysiology and the signaling pathways involved in this process are also shared by the development of MDS-related TOD

It interacts with DNA to form adductssuch as DNADNA and DNAproteins crosslinkswhich activate several signal transduction pathways that trigger cell death 74,76

[38] The following year, Pauling published what he regarded as his most important paper, in which he first laid out the concept of hybridization of atomic orbitals and analyzed the tetravalency of the carbon atom

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