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References 1.Goki N.H., Tehranizadeh Z.A., Saberi M.R., Khameneh B., Bazzaz B.S.F

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when cells are exposed to this stimulus, the NRF2Keap1 complex is disrupted, allowing NRF2 to escape and resulting in Keap1-mediated degradation

Structural atrophy of astrocytes leads to a decrease in synaptic coverage and synaptic maintenance thus affecting both excitatoryinhibitory balance and synaptic plasticity 134,135