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There are a couple of reasons a single faulty copy can cause a disease
K.CalcuttN
Antioxidant properties of pyruvate mediate its potentiation of beta-adrenergic inotropism in stunned myocardium
Low Mr phosphotyrosine protein phosphatase interacts with the PDGF receptor directly via its catalytic site
A very helpful study
Chiou and Huang, 1999
