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Dopamine agonists provide a symptomatic benefit that is comparable to that of levodopa/carbidopa in early disease, but these agents lack sufficient efficacy to control signs and symptoms by themselves in more advanced diseases (Hauser & Benbadis, 2020)
Ameliorative effect of riboflavin on hyperglycemia, oxidative stress and DNA damage in type-2 diabetic mice: Mechanistic and therapeutic strategies
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At 5 years, low B12 levels occurred in significantly more participants in the metformin group (4.3%) than in the placebo group (2.3%)
This is where B12 supplements come in
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