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5.2.3 Huangqin decoction HQD has been used clinically in China for over 1800 years to treat gastrointestinal disorders

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These processes involve the activation of muscarinic cholinergic receptors in the forebrain, and an increased expression of type-2 metabotropic glutamate (mGlu2) receptors in dorsal root ganglia neurons

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[111,112] Additionally, restored hepatic heme content should initiate negative feedback mechanism that maintains both heme and ALAS1 activity