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While early activation may serve a protective role by clearing cellular debris, prolonged or excessive activation leads to a shift in phenotype, marked by altered expression of core markers, including the upregulation of inflammatory genes and downregulation of homeostatic functions, which plays a critical role in disease progression and therapeutic targeting (Paolicelli et al., 2022)

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However, individuals with refined diets or those following vegetarian lifestyles may need supplements

doi: 10.3389/fncel.2015.00003

Ernst, J

it is a question of identifying whether your skin is currently starved for structural architecture or antioxidant defense