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Neurogenic inflammatory processes occurring in peripheral structures and within the central nervous system (spinal cord and brain) have been correlated through studies of fibromyalgia pathophysiology [58,60,61]

However, more research is needed on their biodegradability, biocompatibility, and potential toxicity

WO 2007106859 A2 20070920

2.5 Study selection Due to the current absence of clinical studies exploring the impacts of innovative immunomodulatory approaches on individuals with neuroinflammatory diseases, our review deliberately narrowed its focus

The biochemical mechanism underlying its essential vitamin function, however, is still unknown

This suggests that intranasally or orally delivered (nose-to-brain) formulations of such complexes may be suitable for preventing or treating neurodegenerative diseases