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While rodents exhibit depression-like behaviors (e.g., anhedonia in sucrose preference tests) after chronic ethanol exposure, human depression is a multifaceted construct encompassing emotional, cognitive, and somatic symptoms (Olney et al

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Copper Delivery Copper is an essential cofactor for enzymes such as lysyl oxidase (involved in collagen and elastin crosslinking) and superoxide dismutase (antioxidant defense)

Symptoms typically peaked during dose escalation and tapered during maintenance

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The glitazars paradox: cardiotoxicity of the metabolically beneficial dual PPAR and PPAR activation