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Description
Endocr Relat Cancer 2012
However, Glp1r/ mice treated with the GLP-1/Gcg coagonist experienced a reduction in body weight and fat mass but did not have improvements in glucose tolerance indicating that GLP-1R agonism is required to counteract the hyperglycemic effects of GcgR agonism (Day et al., 2013)
For example, the Ozempic (semaglutide) prescribing information notes injection site reactions in 1.2% of patients, while Trulicity (dulaglutide) reports injection site reactions in 0.7% of patients
10.3389/fimmu.2020.01301 20 Ozempic (2022)
P., Klingenberg, L., Astrup, A., & Sjdin, A
Foundational mechanism paper
